New Coronavirus D614G accelerated replication


Mutation of New Coronavirus D614G, which may lead to accelerated replication

On July 3, local time, WHO chief scientist Sumia Swaminathan said at a routine conference on New Coronary Pneumonia that laboratory research found that the mutation of New Coronavirus D614G may lead to accelerated virus replication, meaning it may be enhanced Its spreadability.

Maria Van Kokhov, technical director of the WHO Health Emergency Program, said that in fact, the D614G mutation was discovered in February, and this mutation has already appeared in the early viral gene sequences found in Europe and other places. Studies have shown that 29% of new coronaviruses The samples showed this variation.

The Chinese Center for Disease Control and Prevention released the new crown epidemic situation and viral genome sequence data in Beijing's new development site on June 18. It mainly includes genomic sequence data of confirmed cases in Beijing (NMDC60013902-01, NMDC60013903-02) and genomic sequence data of environmental samples (NMDC60013903-03). These three samples were collected on June 11, 2020, which was the cause of the recent recurrence of the Beijing epidemic. Virus samples. Researchers have compared the previous data and found that all three groups of virus samples have D614G mutations.

The Los Alamos National Laboratory published a paper online in the top academic journal "Cell" on July 2nd. This study believes that their findings believe that the SARS-CoV-2 mutant strain carrying the S protein D614G It has become the most common form of global pandemic, and the mutated virus has proved more contagious.

The researchers came from Los Alamos National Laboratory in New Mexico, Duke University in North Carolina, and collaborated with the University of Sheffield outbreak team to analyze and publish the global shared influenza Gene samples from the Data Initiative (GISAID).

The research team also found that a higher viral load than before the mutation suggested that the D614G mutant virus was associated with a higher level of viral nucleic acid in the patient's upper respiratory tract. However, the paper also pointed out that "we found that there is no significant relationship between D614G and the severity of the disease." The research team also proposed that the G614 mutant pseudovirus is related to higher infectivity. Quantitative analysis shows that the proportion of virus particles carrying the G614 mutation corresponds to D614 has a significantly higher infectious titer, an increase of 2.6 to 9.3 times, perhaps explaining why it can spread more easily around the world.
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